ResearchScience

Breakthrough Study Reveals Novel Protein Regulating Malaria Parasite’s Key Survival Mechanism

Researchers have determined the first endogenous structure of PfATP4, a crucial malaria parasite protein. The study reveals an unexpected companion protein that appears essential for parasite survival and drug resistance mechanisms.

Structural Breakthrough in Malaria Research

Scientists have achieved a significant milestone in understanding malaria parasite biology by determining the first endogenous structure of PfATP4, according to recent reports. The research, conducted using cryogenic electron microscopy at 3.7 Ångström resolution, reveals unprecedented details about this crucial antimalarial target isolated directly from parasite-infected human red blood cells.