A major virology discovery reveals that HKU25 clade coronaviruses, previously thought to use DPP4 receptors like MERS, actually utilize ACE2 – the same entry point as SARS-CoV-2. This receptor switch dramatically changes pandemic risk assessment for these widespread bat viruses.
Scientists have discovered a previously unknown protein insertion system in fungi that operates alongside the well-established SEC61 pathway. The SND3 translocon complex shows unique structural features that could revolutionize our understanding of membrane protein biogenesis.
Researchers have determined the first endogenous structure of PfATP4, a crucial malaria parasite protein. The study reveals an unexpected companion protein that appears essential for parasite survival and drug resistance mechanisms.
Scientists have achieved a significant milestone in understanding malaria parasite biology by determining the first endogenous structure of PfATP4, according to recent reports. The research, conducted using cryogenic electron microscopy at 3.7 Ångström resolution, reveals unprecedented details about this crucial antimalarial target isolated directly from parasite-infected human red blood cells.
