BiotechnologyHealthcareResearch

Breakthrough Epigenetic Editing Enables Durable Gene Silencing in Human T Cells Without DNA Damage

Researchers have demonstrated a new epigenetic editing approach that provides durable gene silencing in primary human T cells without causing DNA damage. The technology, called CRISPRoff, maintains gene repression through multiple cell divisions and shows minimal cellular toxicity compared to traditional CRISPR-Cas9 methods. This breakthrough could significantly advance cell therapy development and genetic research applications.

Revolutionary Epigenetic Editing Platform

Scientists have developed a groundbreaking epigenetic editing technology that can permanently silence genes in human immune cells without altering the underlying DNA sequence, according to research published in Nature Biotechnology. The approach, reportedly called CRISPRoff, enables durable gene repression that persists through approximately 30-80 cell divisions, representing a significant advancement over previous temporary gene silencing methods.

BusinessGovernmentHealthcare

NSW Government to Acquire Northern Beaches Hospital in $190 Million Public Takeover

The New South Wales government has reached an in-principle agreement to purchase the Northern Beaches Hospital for $190 million, according to reports. The acquisition would end a decade of private operation and integrate the facility into the public hospital system, though medical staff express concerns about reduced patient choice.

Major Healthcare Transition

The New South Wales government will reportedly spend $190 million to acquire the Northern Beaches Hospital from private operators, according to sources familiar with the agreement. The purchase would mark the end of a decade-long experiment with private ownership of a major Sydney healthcare facility and integrate it fully into the public hospital system.